منابع مشابه
SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
An important requirement for physiologic homeostasis is the detoxification and removal of endogenous hormones and xenobiotic compounds with biological activity. Much of the detoxification is performed by cytochrome P-450 enzymes, many of which have broad substrate specificity and are inducible by hundreds of different compounds, including steroids. The ingestion of dietary steroids and lipids i...
متن کاملMolecular chaperones function as steroid receptor nuclear mobility factors.
Live cell imaging has revealed the rapid mobility of steroid hormone receptors within nuclei and their dynamic exchange at transcriptionally active target sites. Although a number of other proteins have been shown to be highly mobile within nuclei, the identity of soluble factors responsible for orchestrating nuclear trafficking remains unknown. We have developed a previously undescribed in sit...
متن کاملControl of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) w...
متن کاملNuclear Quadrupole Coupling Tensors
By single crystal NMR the nuclear quadrupole coupling constants eQ,.h~ (H), the asymmetry parameters >/(H) and the dircetion cosines of the principal axes of the electric field gradient tensors of the H atoms of the two kinds of D 2 0 molecules have been determined at 295 K in RbAl(S04)2 • 1 2 D 2 0 . The results show that the D 2 0 molecules surrounding the ion Al + are "static" within the ...
متن کاملheterozygous inactivation of the nuclear receptor pxr/nr1i2 in a patient with anabolic steroid-induced intrahepatic cholestasis
introduction the incidence of liver damage due to steroid consumption is increasing due to the omnipresence of the idealized body image and the widespread availability of drugs via the internet. the genetic factors underlying individual susceptibility are not presently known. conclusions this case of pxr haploinsufficiency reveals transcriptional regulatory functions activated in the liver unde...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2012
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2012.06.001